Publications

Genetic Variants of Adrenoreceptors. In: Handbook of Experimental Pharmacology.


Ahles, A., Engelhardt, S.


Springer, Berlin, Heidelberg. 2023. 1-28(link is external)


Immobility-associated thromboprotection is conserved across mammalian species from bear to human


Manuela Thienel, Johannes B. Müller-Reif, Zhe Zhang, Vincent Ehreiser, Judith Huth, Khrystyna Shuchurovska, Badr Kilani, Lisa Schweizer, Philipp E. Geyer, Maximilian Zwiebel, Julia Novotny, Enzo Lüsebrink, Gemma Little, Martin Orban, Leo Nicolai, Shaza El Nemr, Anna Titova, Michael Spannagl, Jonas Kindberg, Alina L. Evans, Orpheus Mach, Matthias Vogel, Steffen Tiedt, Steffen Ormanns, Barbara Kessler, Anne Dueck, Andrea Friebe, Peter Godsk Jørgensen, Monir Majzoub-Altweck, Andreas Blutke, Amin Polzin, Konstantin Stark, Stefan Kääb, Doris Maier, Jonathan M. Gibbins, Ulrich Limper, Ole Frobert, Matthias Mann, Steffen Massberg, Tobias Petzold.


Science. 2023. Vol 380, Issue 6641.(link is external)

Publications



Aging promotes reactivation of the Barr body at distal chromosome regions


Sarah Hoelzl, Tim P. Hasenbein, Stefan Engelhardt, Daniel Andergassen

Nature Aging 2025

Ganglionic Inflammation in a Patient With Takotsubo Syndrome


Karin A Ziegler, Manuel Zeitler, Sandro Meunier, Inga Sinicina, Tim P Hasenbein, Daniel Andergassen, Anton Bomhard, Reginald VCT van der Kwast, Stefan Engelhardt

Circulation 2025

X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes


Tim P. Hasenbein, Sarah Hoelzl, Zachary D. Smith, Chiara Gerhardinger, Marion O. C. Gonner, Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Nathalia R. V. Dragano, Patricia da Silva-Buttkus, Lillian Garrett, Sabine M. Hölter, Markus Kraiger, Manuela A. Östereicher, Birgit Rathkolb, Adrián Sanz-Moreno, Nadine Spielmann, Wolfgang Wurst, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Alexander Meissner, Stefan Engelhardt, John L. Rinn, Daniel Andergassen.

Nature Communications volume 15, Article number: 10631 (2024)

Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis.


Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, van den Heuvel D, Belz L, Sobirova G, Zhang Z, Titova A, Navarro AM, Pekayvaz K, Lorenz M, von Baumgarten L, Kranich J, Straub T, Popper B, Zheden V, Kaufmann WA, Guo C, Piontek G, von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Brocker T, Walzog B, Scheiermann C, Aird WC, Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendorp RAJ, Iannacone M, Heinig M, Massberg S.

Nature. 2024

Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia.


Weinberger T, Denise M, Joppich M, Fischer M, Garcia Rodriguez C, Kumaraswami K, Wimmler V, Ablinger S, Räuber S, Fang J, Liu L, Liu WH, Winterhalter J, Lichti J, Thomas L, Esfandyari D, Percin G, Matin S, Hidalgo A, Waskow C, Engelhardt S, Todica A, Zimmer R, Pridans C, Gomez Perdiguero E, Schulz C.

Elife. 2024.12:RP89377.

Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy.


Sultan I, Ramste M, Peletier P, Hemanthakumar KA, Ramanujam D, Tirronen A, von Wright Y, Antila S, Saharinen P, Eklund L, Mervaala E, Ylä-Herttuala S, Engelhardt S, Kivelä R, Alitalo K.

Circ Res. 2024. 134(11):1465-1482.

In Vivo Silencing of Regulatory Elements Using a Single AAV-CRISPRi Vector.


Laurette P, Cao C, Ramanujam D, Schwaderer M, Lueneburg T, Kuss S, Weiss L, Dilshat R, Furlong EEM, Rezende F, Engelhardt S, Gilsbach R.

Circ Res. 2024. 134(2):223-225.

Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype.


Maus M, López-Polo V, Mateo L, Lafarga M, Aguilera M, De Lama E, Meyer K, Sola A, Lopez-Martinez C, López-Alonso I, Guasch-Piqueras M, Hernandez-Gonzalez F, Chaib S, Rovira M, Sanchez M, Faner R, Agusti A, Diéguez-Hurtado R, Ortega S, Manonelles A, Engelhardt S, Monteiro F, Stephan-Otto Attolini C, Prats N, Albaiceta G, Cruzado JM, Serrano M.

 Nat Metab. 2023. 5(12):2111-2130.

Protective effects of Gαi3 deficiency in a murine heart-failure model of β1-adrenoceptor overexpression.


Schröper T, Mehrkens D, Leiss V, Tellkamp F, Engelhardt S, Herzig S, Birnbaumer L, Nürnberg B, Matthes J.

Naunyn Schmiedebergs Arch Pharmacol. 2023. 397(4):2401-2420.

Identification of hypertrophy-modulating Cullin-RING ubiquitin ligases in primary cardiomyocytes.


Fischer M, Jakab M, Hirt MN, Werner TR, Engelhardt S, Sarikas A.

 Front Physiol. 2023. 14:1134339.

The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies.


Hoffmann J, Hanß S, Kraus M, Schaller J, Schäfer C, Stahl D, Anker SD, Anton G, Bahls T, Blankenberg S, Blumentritt A, Boldt LH, Cordes S, Desch S, Doehner W, Dörr M, Edelmann F, Eitel I, Endres M, Engelhardt S, Erdmann J, Eulenburg K, Falk V, Felix SB, Frank D, Franke T, Frey N, Friede T, Geidel L, Germans L, Grabmaier U, Halle M, Hausleiter J, Jakobi V, Jebran AF, Jobs A, Kääb S, Karakas M, Katus HA, Klatt A, Knosalla C, Krebser J, Landmesser U, Lee M, Lehnert K, Lesser S, Leyh K, Lorbeer R, Mach-Kolb S, Meder B, Nagel E, Nolte CH, Parwani AS, Petersmann A, Puls M, Rau H, Reiser M, Rienhoff O, Scharfe T, Schattschneider M, Scheel H, Schnabel RB, Schuster A, Schmitt B, Seidler T, Seiffert M, Stähli BE, Stas A, J Stocker T, von Stülpnagel L, Thiele H, Wachter R, Wakili R, Weis T, Weitmann K, Wichmann HE, Wild P, Zeller T, Hoffmann W, Zeisberg EM, Zimmermann WH, Krefting D, Kühne T, Peters A, Hasenfuß G, Massberg S, Sommer T, Dimmeler S, Eschenhagen T, Nauck M.

Clin Res Cardiol. 2023. 112(7):923-941.

Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease


Karin A Ziegler, Andrea Ahles, Anne Dueck, Dena Esfandyari, Pauline Pichler, Karolin Weber, Stefan Kotschi, Alexander Bartelt, Inga Sinicina, Matthias Graw, Heinrich Leonhardt, Ludwig T Weckbach, Steffen Massberg, Martina Schifferer, Mikael Simons, Luciano Hoeher, Jie Luo, Ali Ertürk, Gabriele G Schiattarella, Yassine Sassi, Thomas Misgeld, Stefan Engelhardt

Science. 2023, 381,285-290.

Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage


Christina Beck, Deepak Ramanujam, Paula Vaccarello, Florenc Widenmeyer, Martin Feuerherd, Cho-Chin Cheng, Anton Bomhard, Tatiana Abikeeva, Julia Schädler, Jan-Peter Sperhake, Matthias Graw, Seyer Safi, Hans Hoffmann, Claudia A. Staab-Weijnitz, Roland Rad, Ulrike Protzer, Thomas Frischmuth, Stefan Engelhardt

Nat Commun. 2023. 14, 4564.

Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus


Fangfang Zhang, Anna B Meier, Daniel Sinnecker, Stefan Engelhardt, Peter Lipp, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti

Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing


Palgit-S. Kogan, Felix Wirth, Archana Tomar, Jonatan Darr, Raffaele Teperino, Harald Lahm, Martina Dreßen, Nazan Puluca, Zhong Zhang, Irina Neb, Nicole Beck, Tatjana Luzius, Luis de la Osa de la Rosa, Kathrin Gärtner, Corinna Hüls, Reinhard Zeidler, Deepak Ramanujam, Stefan Engelhardt, Catharina Wenk, Lesca M. Holdt, Mimmi Mononen, Makoto Sahara, Julie Cleuziou, Jürgen Hörer, Rüdiger Lange, Markus Krane & Stefanie A. Doppler

Genetic Variants of Adrenoceptors.


Ahles A, Engelhardt S.

 Handb Exp Pharmacol. 2023

CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver


Thorsten Kaltenbacher, Jessica Löprich, Roman Maresch, Julia Weber, Sebastian Müller, Rupert Oellinger, Nina Groß, Joscha Griger, Niklas de Andrade Krätzig, Petros Avramopoulos, Deepak Ramanujam, Sabine Brummer, Sebastian A. Widholz, Stefanie Bärthel, Chiara Falcomatà, Anja Pfaus, Ahmed Alnatsha, Julia Mayerle, Marc Schmidt-Supprian, Maximilian Reichert, Günter Schneider, Ursula Ehmer, Christian J. Braun, Dieter Saur, Stefan Engelhardt, Roland Rad

Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling


Melina Lopez, Pedro F. Malacarne, Deepak P. Ramanujam, Timothy Warwick, Niklas Müller, Jiong Hu, Matthias Dewenter, Andreas Weigert, Stefan Günther, Ralf Gilsbach, Stefan Engelhardt, Ralf P. Brandes, Flávia Rezende

MicroRNAs as therapeutic targets in cardiovascular disease


Bernhard Laggerbauer, Stefan Engelhardt

Nicht kodierende Ribonukleinsäure im kardiovaskulären System


S. Engelhardt, S. Dimmeler, C. Heim, C. Bär, T. Böttger, R. Boon, R. P. Brandes, T. Braun, A. Dueck, J. Gagneur, P.Grote, L.M. Holdt, N. Jaé , J. Krishnan, C. Kupatt, K.-L. Laugwitz, M. S. Leisegang, L. Maegdefessel, T. Meitinger, A. Moretti, M. Müller-McNicoll, M. Sattler, A. Schnieke, M. Schulz, H. Schunkert, H. Schwalbe, D. Teupser, T. Thum, C.Weber, I. Wittig, K. Zarnack

MicroRNA-365 regulates human cardiac action potential duration


Esfandyari D, Idrissou BMG, Hennis K, Avramopoulos P, Dueck A, El-Battrawy I, Grüter L, Meier MA, Näger AC, Ramanujam D, Dorn T, Meitinger T, Hagl C, Milting H, Borggrefe M, Fenske S, Biel M, Dendorfer A, Sassi Y, Moretti A, Engelhardt S

The long non-coding RNA NRON promotes the development of cardiac hypertrophy in the murine heart


Jeannine Hoepfner, Julia Leonardy, Dongchao Lu, Kevin Schmidt, Hannah J Hunkler, Sinje Biß, Ariana Foinquinos, Ke Xiao, Kumarswamy Regalla, Deepak Ramanujam, Stefan Engelhardt, Christian Bär, Thomas Thum 

From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo


Daniel Andergassen, John L Rinn

Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages


Daniel Andergassen, Zachary D Smith, Helene Kretzmer, John L Rinn, Alexander Meissner

Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing


Anke J Tijsen, Lucía Cócera Ortega, Yolan J Reckman, Xiaolei Zhang, Ingeborg van der Made, Simona Aufiero, Jiuru Li, Selina C Kamps, Anouk van den Bout, Harsha D Devalla, Karin Y van Spaendonck-Zwarts, Stefan Engelhardt, Lior Gepstein, James S Ware, Yigal M Pinto

Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p


George Haddad, Malte Kölling, Urs A Wegmann, Angela Dettling, Harald Seeger, Roland Schmitt, Inga Soerensen-Zender, Hermann Haller, Andreas D Kistler, Anne Dueck, Stefan Engelhardt, Thomas Thum, Thomas F Mueller, Rudolf P Wüthrich, Johan M Lorenzen

Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis.


Haberman ER, Sarker G, Arús BA, Ziegler KA, Meunier S, Martínez-Sánchez N, Freibergerová E, Yilmaz-Özcan S, Fernández-González I, Zentai C, O'Brien CJO, Grainger DE, Sidarta-Oliveira D, Chakarov S, Raimondi A, Iannacone M, Engelhardt S, López M, Ginhoux F, Domingos AI.

Immunity. 2024. 57(1):141-152.e5.

Glycosylation-dependent cleavage of the human β 1-adrenoceptor


Andrea Ahles, Stefan Engelhardt 

DGK and DZHK position paper on genome editing: basic science applications and future perspective


Ralf P Brandes, Anne Dueck, Stefan Engelhardt, Manuel Kaulich, Christian Kupatt, Maria Teresa De Angelis, Matthias S Leisegang, Ferdinand le Noble, Alessandra Moretti, Oliver J Müller, Boris V Skryabin, Thomas Thum, Wolfgang Wurst 

Completion of neuronal remodeling prompts myelination along developing motor axon branches


Mengzhe Wang, Tatjana Kleele, Yan Xiao, Gabriela Plucinska, Petros Avramopoulos, Stefan Engelhardt, Markus H Schwab, Matthias Kneussel, Tim Czopka, Diane L Sherman, Peter J Brophy, Thomas Misgeld, Monika S Brill

MicroRNA-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload


Deepak Ramanujam, Anna Patricia Schön, Christina Beck, Paula Vaccarello, Giulia Felician, Anne Dueck, Dena Esfandyari, Gunter Meister, Thomas Meitinger, Christian Schulz, Stefan Engelhardt

Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis


Melanie Anger, Florian Scheufele, Deepak Ramanujam, Kathleen Meyer , Hidehiro Nakajima , Loren J Field, Stefan Engelhardt, Antonio Sarikas

Metavinculin modulates force transduction in cell adhesion sites.


Kanoldt V, Kluger C, Barz C, Schweizer AL, Ramanujam D, Windgasse L, Engelhardt S, Chrostek-Grashoff A, Grashoff C

Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation.


Weinberger T, Esfandyari D, Messerer D, Percin G, Schleifer C, Thaler R, Liu L, Stremmel C, Schneider V, Vagnozzi RJ, Schwanenkamp J, Fischer M, Busch K, Klapproth K, Ishikawa-Ankerhold H, Klösges L, Titova A, Molkentin JD, Kobayashi Y, Engelhardt S, Massberg S, Waskow C, Perdiguero EG, Schulz C 

Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart.


Bär C, Chatterjee S, Falcão Pires I, Rodrigues P, Sluijter JPG, Boon RA, Nevado RM, Andrés V, Sansonetti M, de Windt L, Ciccarelli M, Hamdani N, Heymans S, Figuinha Videira R, Tocchetti CG, Giacca M, Zacchigna S, Engelhardt S, Dimmeler S, Madonna R, Thum T

LifeTime and improving European healthcare through cell-based interceptive medicine.


Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni J, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.


Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schürmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jaé N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S, Boon RA

Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy.


Viereck J, Bührke A, Foinquinos A, Chatterjee S, Kleeberger JA, Xiao K, Janssen-Peters H, Batkai S, Ramanujam D, Kraft T, Cebotari S, Gueler F, Beyer AM, Schmitz J, Bräsen JH, Schmitto JD, Gyöngyösi M, Löser A, Hirt MN, Eschenhagen T, Engelhardt S, Bär C, Thum T

AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury.


Hinkel R, Ramanujam D, Kaczmarek V, Howe A, Klett K, Beck C, Dueck A, Thum T, Laugwitz KL, Maegdefessel L, Weber C, Kupatt C, Engelhardt S

Correlation of online assessment parameters with summative exam performance in undergraduate medical education of pharmacology: a prospective cohort study.


Kühbeck F, Berberat PO, Engelhardt S, Sarikas A

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity.


Gupta SK, Garg A, Avramopoulos P, Engelhardt S, Streckfuss-Bömeke K, Batkai S, Thum T

Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R.


Olivares-Florez S, Czolbe M, Riediger F, Seidlmayer L, Williams T, Nordbeck P, Strasen J, Glocker C, Jänsch M, Eder-Negrin P, Arias-Loza P, Mühlfelder M, Plačkić J, Heinze KG, Molkentin JD, Engelhardt S, Kockskämper J, Ritter O

H19 Induces Abdominal Aortic Aneurysm Development and Progression.


Li DY, Busch A, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S, Lao S, Hofmann P, Bäcklund A, Eken SM, Roy J, Eriksson P, Dacken B, Ramanujam D, Dueck A, Engelhardt S, Boon RA, Eckstein HH, Spin JM, Tsao PS, Maegdefessel L

Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice.


Ziegler KA, Ahles A, Wille T, Kerler J, Ramanujam D, Engelhardt S

Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling.


Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.


Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S

Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload.


Toischer K, Zhu W, Hünlich M, Mohamed BA, Khadjeh S, Reuter SP, Schäfer K, Ramanujam D, Engelhardt S, Field LJ, Hasenfuss G

Preferential microRNA targeting revealed by in vivo competitive binding and differential Argonaute immunoprecipitation.


Werfel S, Leierseder S, Ruprecht B, Kuster B, Engelhardt S

Two serines in the distal C-terminus of the human β1-adrenoceptor determine β-arrestin2 recruitment.


Hinz, L, Ahles, A, Ruprecht, B, Küster, B, Engelhardt, S

Circular RNAs in heart failure.


Devaux Y, Creemers EE, Boon RA, Werfel S, Thum T, Engelhardt S, Dimmeler S, Squire I

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives.


Poller W, Dimmeler S, Heymans S, Zeller T, Haas J, Karakas M, Leistner DM, Jakob P, Nakagawa S, Blankenberg S, Engelhardt S, Thum T, Weber C, Meder B, Hajjar R, Landmesser U

Iron deficiency anemia in cyclic gmp kinase knockout mice.


Angermeier E, Domes K, Lukowski R, Schlossmann J, Rathkolb B, Angelis MH, Hofmann F

Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.


Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall W., Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW

Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin.


Wetzl V, Schinner E, Kees F, Hofmann F, Faerber L, Schlossmann J

Viral Vector-Based Targeting of miR-21 in Cardiac Nonmyocyte Cells Reduces Pathologic Remodeling of the Heart.


Ramanujam D, Sassi Y, Laggerbauer B, Engelhardt S

Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.


Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, Calzada-Wack J, Koenen RR, Braun A, Nieswandt B, Engelhardt S

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.


Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T

Characterization of circular RNAs in human, mouse and rat hearts.


Werfel S, Nothjunge S, Schwarzmayr T, Strom TM, Meitinger T, Engelhardt S

Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis.


Meyer K, Hodwin B, Ramanujam D, Engelhardt S, Sarikas A

Long noncoding RNA Chast promotes cardiac remodeling.


Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M5, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T

MicroRNA Augmentation of Bone Marrow-Derived Cell Therapy.


Engelhardt S, Sassi Y

MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.


Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, Döhner H, Buske C, Jongen-Lavrencic M, Naldini L, Humphries RK, Kuchenbauer F

Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice.


Keller K, Maass M, Dizayee S, Leiss V, Annala S, Köth J, Seemann WK, Müller-Ehmsen J, Mohr K, Nürnberg B, Engelhardt S, Herzig S, Birnbaumer L, Matthes J

Murine cardiac growth, TRPC channels, and cGMP kinase I.


Domes K, Patrucco E, Loga F, Dietrich A, Birnbaumer L, Wegener JW, Hofmann F

Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration.


Limmer F, Schinner E, Castrop H, Vitzthum H, Hofmann F, Schlossmann J

Development of an intein-mediated split-Cas9 system for gene therapy.


Truong DJ, Kühner K, Kühn R, Werfel S, Engelhardt S, Wurst W, Ortiz O

Intercellular miRNA Traffic.


Ramanujam D, Engelhardt S

Use of learning media by undergraduate medical students in pharmacology: a prospective cohort study.


Gutmann J, Kühbeck F, Berberat PO, Fischer MR, Engelhardt S, Sarikas A

Interhelical interaction and receptor phosphorylation regulate the activation kinetics of different human β1-adrenoceptor variants.


Ahles A, Rodewald F, Rochais F, Bünemann M, Engelhardt S

Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.


Sassi Y, Ahles A, Truong DJ, Baqi Y, Lee SY, Husse B, Hulot JS, Foinquinos A, Thum T, Müller CE, Dendorfer A, Laggerbauer B, Engelhardt S

FHL2 expression and variants in hypertrophic cardiomyopathy.


Friedrich FW, Reischmann S, Schwalm A, Unger A, Ramanujam D, Münch J, Müller OJ, Hengstenberg C, Galve E, Charron P, Linke WA, Engelhardt S, Patten M, Richard P, van der Velden J, Eschenhagen T, Isnard R, Carrier L

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase.


Werfel S, Jungmann A, Lehmann L, Ksienzyk J, Bekeredjian R, Kaya Z, Leuchs B, Nordheim A, Backs J, Engelhardt S, Katus HA, Müller OJ

Accuracy and completeness of drug information in Wikipedia: a comparison with standard textbooks of pharmacology.


Kräenbring J, Monzon Penza T, Gutmann J, Muehlich S, Zolk O, Wojnowski L, Maas R, Engelhardt S, Sarikas A

Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease.


Ahles A, Engelhardt S

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy.


Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T

OnlineTED.com-a novel web-based audience response system for higher education. A pilot study to evaluate user acceptance.


Kühbeck F, Engelhardt S, Sarikas A

CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.


Yang G, Shi Y, Yu J, Li Y, Yu L, Welling A, Hofmann F, Striessnig J, Juntti-Berggren L, Berggren PO, Yang SN

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.


Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM, Rorsman P

Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen.


Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, Hurwitz J, Pan ZQ, Engelhardt S, Sarikas A

Reduced excitability of gp130-deficient nociceptors is associated with increased voltage-gated potassium currents and Kcna4 channel upregulation.


Langeslag M, Malsch P, Welling A, Kress M

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.


Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, Muehlich S, Pfeiffer AF, Field LJ, Charron MJ, Pan ZQ, Engelhardt S, Sarikas A

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.


Bellin M, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D, Tertoolen LG, Jung CB, Elliott DA, Welling A, Laugwitz KL, Moretti A, Mummery CL

Coinciding functions for miR-145 in vascular smooth muscle and cardiac fibroblasts.


Engelhardt S, Leierseder S

microRNA-22 Promotes Heart Failure through Coordinate Suppression of PPAR/ERR-Nuclear Hormone Receptor Transcription.


Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A

MiR-223 is dispensable for platelet production and function in mice.


Leierseder S, Petzold T, Zhang L, Loyer X, Massberg S, Engelhardt S

Dynamics of Gαi1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production.


Milde M, Rinne A, Wunder F, Engelhardt S, Bünemann M

The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance.


Rinck A, Preusse M, Laggerbauer B, Lickert H, Engelhardt S, Theis FJ

MiR-378 Controls Cardiac Hypertrophy by Combined Repression of MAP Kinase Pathway Factors.


Ganesan J, Ramanujam D, Sassi Y, Ahles A, Jentzsch C, Werfel S, Leierseder S, Loyer X, Giacca M, Zentilin L, Thum T, Laggerbauer B, Engelhardt S

Internet discussion forums as part of a student-centred teaching concept of pharmacology.


Sucha M, Engelhardt S, Sarikas A

Pharmacases.de - a student-centered e-learning project of clinical pharmacology.


Zollner B, Sucha M, Berg C, Muß N, Amann P, Amann-Neher B, Oestreicher D, Engelhardt S, Sarikas A

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.


Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M, Batkai S, Dangwal S, Kumarswamy R, Bang C, Holzmann A, Remke J, Caprio M, Jentzsch C, Engelhardt S, Geisendorf S, Glas C, Hofmann TG, Nessling M, Richter K, Schiffer M, Carrier L, Napp LC, Bauersachs J, Chowdhury K, Thum T

Small RNA biomarkers come of age.


Engelhardt S

The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice.


Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schönberger T, Jürgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet T, Gawaz M

Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.


Sassi Y, Abi-Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, Kranias EG, Marks AR, Lacampagne A, Engelhardt S, Hatem SN, Lompre AM, Hulot JS

A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes.


Jentzsch C, Leierseder S, Loyer X, Flohrschütz I, Sassi Y, Hartmann D, Thum T, Laggerbauer B, and Engelhardt S

MicroRNA-24 regulates vascularity after myocardial infarction.


Fiedler J, Jazbutyte V, Kirchmaier B, Galuppo P, Kneitz S, Pena JTR, Sohn-Lee C, Soutschek J, Brand T, Tuschl T, Ertl G, Engelhardt S, Bauersachs J, Thum T

A critical role for STIM1 in cardiac hypertrophy.


Hulot JS, Fauconnier J, Ramanujam D, Chaanine A, Aubart F, Sassi Y, Merkle S, Cazorla O, Ouille A, Dupuis M, Hadri L, Jeong D, Muehlstedt S, Schmitt J, Braun A, Benard L, Saliba Y, Laggerbauer B, Nieswandt B, Lacampagne A, Hajjar R, Lompre AM, and Engelhardt S

A Polymorphism-Specific "Memory" Mechanism in the β2-Adrenergic Receptor.


Ahles A, Rochais F, Frambach T, Bünemann M and Engelhardt S

Facilitation and Ca2+-dependent Inactivation Are Modified by Mutation of the Cav1.2 Channel IQ Motif.


Poomvanicha M, Wegener JW, Blaich A, Fischer S, Domes K, Moosmang S, Hofmann F

Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion.


Seizer P, Ochmann C, Schönberger T, Zach S, Rose M, Borst O, Klingel K, Kandolf R, MacDonald HR, Nowak RA, Engelhardt S, Lang F, Gawaz M, May AE