Publications

Publications



Insights into cGMP signalling derived from cGMP kinase knockout mice.


Schlossmann J, Feil R & Hofmann F

Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice.


Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou XB, Sausbier U, Feil S, Kamm S, Essin K, Sailer CA, Adullah U, Krippeit-Drews P, Feil R, Hofmann F, Knaus HG, Kenyon C, Shipston MJ, Storm JF, Neuhuber W, Korth M, Schubert R, Gollasch M & Ruth P

cGMP-dependent protein kinases in drug disvovery.


Schlossmann J & Hofmann F

Bedeutung des Schrittmacherkanals HCN4 im embryonalen Herzen der Maus.


Stieber J

Biospektrum 2005, 2, 213 – 214

Functional expression of the human HCN3 channel.


Stieber J, Stöckl G, Herrmann S, Hassfurth B & Hofmann F

Effects of polyphenols and magnesium on functions of heart and vascular smooth muscle: similarities and differences.


Vierling W, Sontia B, Müller B & Wagner H

In Biopolyphenol und Magnesium – Südsteirische Schätze, eds S. Porta and D. Gualtieri, 1st edition 2005, 104 – 116 (Edition B, Graz, Österreich)

25th Magnesium-Symposium of the Society of Magnesium Research, 8.-9. Okt. 2004 in München.


Vierling W

J. Trace Elem. Electrolytes Health Dis. 2005, 22, 160 – 168

Inhibition of L-type Cav1.2 Ca2+ -channels by 2,(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Gö6983).


Welling A, Hofmann F & Wegener JW

Neutrophil dysfunction in guanosine 3`,5`-cyclic monophosphate-dependent protein kinase I-deficient mice.


Werner CG, Godfrey V, Arnold RR, Featherstone GL, Bender D, Schlossmann J, Schiemann M, Hofmann F & Pryzwansky KB

Cyclic Nucleotide-Regulated Cation Channels.


Biel M & Hofmann F

In Encyclopedia of Biological Chemistry, eds. Lennarz, W. u. Lane, M.D., Elsevier Science (USA) 2004, Volume 1, 512-515

Entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.


Brill J, Klocke R, Paul D, Boison D, Gouder N, Klugbauer N, Hofmann F, Becker CM & Becker K

Vasodilating properties of the stem bark extract of Mitragyna ciliata in rats and guinea pigs.


Dongmo A, Kamanyi MA, Tan PV, Bopelet M, Vierling W & Wagner H

Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation.


Engelhardt S, Hein L, Dyachenkow V, Kranias EG, Isenberg G & Lohse MJ

SM22a Modulates vascular smooth muscle cell phenotype during atherogenesis.


Feil S, Hofmann F & Feil R

Calcium channel function and regulation in beta 1- and beta 2-adrenoceptor transgenic mice.


Foerster K, Kaeferstein T, Groner F, Engelhardt S, Matthes J, Koch WJ, Lohse MJ & Herzig S

InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle.


Fritsch R, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselhöringer A, Hofmann F & Allescher HD

 Distribution of IRAG and cGKI-isoforms in murine tissues.


Geiselhöringer A, Gaisa M, Hofmann F & Schlossmann J

IRAG is essential for relaxation of receptor-triggered smooth musle contraction by cGMP kinase.


Geiselhöringer A, Werner M, Sigl K, Smital P, Wörner R, Acheo L, Stieber J, Weinmeister P, Feil R, Feil S, Wegener J, Hofmann F & Schlossmann J

Wirkungen von Pharmaka auf den Organismus: allgemeine Pharmakodynamik.


Hofmann F

In Allgemeine und spezielle Pharmakologie und Toxikologie, Eds. Aktories, Förstermann, Hofmann, Starke, 9. Auflage 2004, Urban & Fischer – Verlag, 5 – 25 

Wächter am Herz und Bewußtsein – Schrittmacherkanäle (Pacemaker Channels and the Control of Heart Rhythm and Awarness.


Hofmann F

Sitzungsberichte der Bayerischen Akademie der Wissenschaften, Jahrgang 2001 – 2003, Verlag C.H. Beck 2004, München, 16 – 17

Mouse Models of NO/Natriuretic Peptide/cGMP Kinase Signaling.


Hofmann F, Biel M, Feil R & Kleppisch T

In Transgenic Models in Pharmacology, Eds. Stefan Offermanns u. Lutz Hein, Handbook of Experimental Pharmacology, Springer – Verlag 2004, Vol.159, 95 –130

Molecular basis of pacemaking.


Hofmann F & Stieber J

In Rezeptoren – Mediatoren, Ihre Rolle bei modernen Therapieansätzen, Eds. Michel und Wolf, Schattauer Verlag 2004, 71 – 81

cGMP-dependent protein kinase mediates NO- but not ACh-induced dilations in resistance vessels in vivo.


Koeppen M, Feil R, Siegl D, Feil S, Hofmann F, Pohl U & de Wit C

Hypertension 2004, 44, 952 – 955

HCN Channels: From genes to function.


Ludwig A, Stieber J, Moosmang S, Herrmann S, Biel M & Hofmann F

In „Cardiac Electrophysiology“ From Cell to Bedside, Eds. Zipes & Jalife, 4th Ed. 2004, Saunders, 59 – 65

GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase. 


Marshall SJ, Senis YA, Auger JM, Feil R, Hofmann F, Salmon G, Perterson,JT, Burslem F & Watson SP

Blood 2004, 103, 2601 – 2609

Pulmonary hypertension and right heart failure in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice.


Otto C, Hein L, Brede M, Jahns R, Engelhardt S, Gröne HJ & Schütz G

Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.


Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, Sausbier U, Sailer CA, Feil R, Hofmann F, Korth M, Shipston MJ, Knaus HG, Wolfer DP, Pedroarena CM, Storm JF & Ruth P

PNAS 2004, 101, 9474 – 9478 

Current status of drug receptor nomenclature: receptor closure? The role of NC-IUPHAR.


Spedding M, Foord SM & Hofmann F

Expert Opin. Investig. Drugs 2004, 13, 461 – 464

Pacemaker channels and sinus node arrthythmia.


Stieber J, Hofmann F & Ludwig A

Trends Cardiovas. Med. 2004, 14, 23 – 28

Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.


Tegeder I, Del Turco D, Schmidtko A, Sausbier M, Feil R, Hofmann F, Deller T, Ruth P. & Geisslinger G

PNAS 2004, 101, 3253 – 3257

Institut für Pharmakologie und Toxikologie, Fakultät für Medizin der Technischen Universität München.


Vierling W

In: Geschichte und Wirken der pharmakologischen, klinisch – pharmakologischen und toxikologischen Institute im deutschsprachigen Raum, Ed. A. Philippu, Beerenkamp Verlag Innsbruck 2004, 542 – 546 

An essential role of Cav1.2 L-type calcium channel for urinary bladder function.


Wegener JW, Schulla V, Lee TS, Koller A, Feil S, Feil R, Kleppisch T, Klugbauer N, Moosmang S, Welling A & Hofmann F

 FASEB J. 2004, 18, 1159 – 1161

Importance of NO/cGMP signaling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol.


Werner C, Raivich G, Cowen M, Stekalowa T, Sillaber I. Buters JT, Spanagel R & Hofmann F

Eur. J. Neurosci. 2004, 20, 3498 – 3506

Circadian and short-term regulation of blood pressure and heart rate in transgenic mice with cardiac overexpression of the beta1-adrenoceptor.


Witte K, Engelhardt S, Janssen BJ, Lohse M & Lemmer B

Proteomics strategies in cardiovascular research.


Zerkowski HR, Grussenmeyer T, Matt P, Grapow M, Engelhardt S & Lefkovits I

Vasodilating effect of the root bank extract of Ficus saussureana on guinea pig aorta.


Dongmo AB, Ndom JC, Massoma LD, Dzikouk DG, Fomani M, Kamanyi A & Vierling W

Pharm. Biol. 2003, 41, 371 – 374

Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy.


Eigenthaler M, Engelhardt S, Schinke B, Kobsar A, Schmitteckert E, Gambaryan S, Engelhardt CM, Krenn V, Eliava M, Jarchau T, Lohse MJ, Walter U & Hein L

Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current If and undermines spontaneous beating of neonatal cardiomyocytes.


Er F, Larbig R, Ludwig A, Biel M, Hofmann F, Beuckelmann DJ & Hoppe UC

Circulation 2003, 107, 485 – 489

Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I.


Feil R, Hartmann J, Luo C, Wolfsgruber W, Schilling K, Feil S, Barski JJ, Meyer M, Konnerth A, de Zeeuw CI & Hofmann F

J. Cell Biology 2003, 163, 295 – 302

Cyclic GMP-dependent protein kinases and the cardiovascular system: Insights from genetically modified mice.


Feil R, Lohmann SM, de Jonge H, Walter U & Hofmann F

Circ Res. 2003, 93, 907 – 916 

Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy.


Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF & Vatner DE

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.


Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG & Yau KW

Nature 2003, 424, 76 – 81

Smooth muscle tone regulation.


Hofmann F

In: Encyclopedic Reference of Molecular Pharmacology, Eds. Stefan Offermanns u. Walter Rosenthal, Springer Verlag 2003, 870 – 875

Voltage-dependent Ca2+ - channels.


Hofmann F

In: Encyclopedic Reference of Molecular Pharmacology, Eds. Stefan Offermanns u. Walter Rosenthal, Springer Verlag 2003, 994 - 999

International Union of Pharmacology XLII. Compendium of voltage-gated ion channels: cyclic nucleotide-modulated channels.


Hofmann F, Biel M & Kaupp B

Pharmacol. Rev. 2003, 55, 587 – 589

Effects of cGMP – dependent protein kinase knockouts.


Hofmann F, Feil R, Kleppisch T & Werner C

Handbook of Cell Signaling, ed. R. Bradshaw and E. Dennis, Academic Press 2003, Vol. 2 , 511 – 514

Endothelium mediated aortic relaxation and blood pressure lowering effect of a procyanidin rich fraction of the stembark extracts of Erythrophleum suaveolens.


Kamanyi A, Dongmo AB, Salah MA, Jatsa H, Wagner H, Vierling W & Bopelet M

Pharm. Biol. 2003, 41, 62 – 67

Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory.


Kleppisch T, Wolfsgruber W, Feil S, Allmann R, Wotjak C, Goebbels S, Nave KA, Hofmann F & Feil R

J. Neurosci. 2003, 23, 6005 – 6012

Calcium channel a2d subunits: Differential expression, function and drug binding.


Klugbauer N, Marais E & Hofmann F

J. Bioenerg. and Biomembr. 2003, 35, 639 – 647

Association of phospholamban with a cGMP kinase signaling complex.


Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P & Hofmann F

Biochem. Biophys. Res. Comm. 2003, 300, 155 – 160

A stimulatory role for cGMP-dependent protein kinase in platelet activation.


Li Z, Xi X, Gu M, Feil R, Ye R, Eigenthaler M, Hofmann F & Du X

Cell 2003, 112, 77 – 86

What is the role of beta-adrenergic signaling in heart failure?


Lohse MJ, Engelhardt S & Eschenhagen T

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2.


Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthof, K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M & Hofmann F

EMBO J. 2003, 22, 216 – 224

Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor.


Maack C, Böhm M, Vlaskin L, Dabew E, Lorenz K, Schäfers HJ, Lohse MJ & Engelhardt S

Laboratory acquired infection with recombinant vaccinia virus containing an immunomodulating construct.


Mempel M, Isa G, Klugbauer, N, Meyer H, Wildi G, Ring J, Hofmann F & Hofmann H

J. Invest. Dermatol. 2003, 120, 356 – 358

Dominant role of smooth muscle L-type calcium channel Cav 1.2 role blood pressure regulation.


Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, Hofmann F & Klugbauer N

EMBO J. 2003, 22, 6027 – 6034

Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling.


Mullershausen F, Friebe A, Feil R, Thompson WJ, Hofmann F & Koesling D

J. Cell. Biol. 2003, 160, 719 – 727

Physiology and Pathophysiology of vascular signaling controlled by cyclic guanosine 3´,5´-cyclic monophosphate-dependent protein kinase.


Münzel T, Feil R, Mülsch A, Lohmann SM, Hofmann F & Walter U

Circulation 2003, 108, 2172 – 2183

cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock.


Oster H, Werner C, Magnone MC, Mayser H, Feil R, Seeliger MW, Hofmann F & Albrecht U

Curr. Biol. 2003, 13, 725 – 733

Signaling through NO and cGMP-dependent protein kinases.


Schlossmann J, Feil R & Hofmann F

Ann. Med. 2003, 35, 21 – 27 

Impaired insulin secretion and glucose tolerance in β cell-selective Cav1.2 Ca2+-channel null mice.


Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, Wollheim CB, Rorsman P & Hofmann F

EMBO J. 2003, 22, 3844 – 3854

Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): In Vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation.


Shimizu-Albergine M, Rybalkin SD, Rybalkina IG, Feil R, Wolfsgruber W, Hofmann F & Beavo JA

J. Neurosci. 2003, 23, 6452 – 6459

The hyperpolariation-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart.


Stieber J, Herrmann S, Feil S, Löster J, Feil R, Biel M, Hofmann F & Ludwig A

PNAS 2003, 100, 15235 – 15240

Alterations in the myocardial creatine kinase system precede the development of contractile dysfunction in beta(1)-adrenergic receptor transgenic mice.


Spindler M, Engelhardt S, Niebler R, Wagner H, Hein L, Lohse MJ & Neubauer S

Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.


Stieber J, Thomer A, Much B, Schneider A, Biel M & Hofmann F

J. Biol. Chem. 2003, 278, 33672 – 33680

Pore structure influences gating properties of the T-type Ca2+ channel a1G.


Talavera K, Janssens A, Klugbauer N, Droogmans G & Nilius B

J. Gen. Physiol. 2003, 121, 529 – 540

Extracellular Ca2+ modulates the effects of protons on gating and conduction properties of the T-type Ca2+ channel a1G (Cav3.1).


Talavera K, Janssens A, Klugbauer N, Droogmans G & Nilius B

J. Gen. Physiol. 2003, 121, 511 – 528

Autophosphorylation of cGMP-dependent Protein Kinase Type II.


Vaandrager AB, Hogema BM, Edixhoven M, van den Burg CMM, Bot AGM, Klatt P, Ruth P, Hofmann F, van Damme J, Vandekerckhove J & de Jonge HR

J. Biol. Chem. 2003, 278, 28651 – 28658

Investigation of the pharmaceutical and pharmacological equivalence of different Hawthorn extracts.


Vierling W, Brand N, Gaedcke F, Sensch KH, Schneider E & Scholz M

Phytomedicine 2003, 10, 8 – 16

Voltage-dependent effects of barnidipine in rat vascular smooth muscle.


Wegener JW, Korstanje C & Nawrath H

J. Cardiovasc. Pharmacol. 2003, 42, 218 – 223

Hypothyroidism does not affect the dihydropyridine sensitivity of precontracted murine uterus.


Wegener JW, Lee M & Hofmann F

Can. J. Physiol. Pharmacol. 2003, 81, 890 – 893

A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells.


Wolfsgruber W, Feil S, Brummer S, Kuppinger O, Hofmann F & Feil R

PNAS 2003, 100, 13519 – 13524

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.


Xu M, Welling A, Paparisto S, Hofmann F & Klugbauer N

J. Biol. Chem. 2003, 278, 40837 – 40841